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E-Mail: dpollock@lanl.gov
Office:
Theoretical Biology and Biophysics, MS K7 10
Los Alamos National Laboratory
Los Alamos, New Mexico 87545
Phone: (505) 665-1923 |
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David D. Pollock
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Interests |
Molecular evolution and
evolutionary genetics/ bioinformatics/ genomics. Protein structure evolution
and functional bioinformatics: Mathematical modeling and empirical study.
Interaction of sequence evolution and protein structure. Analysis of molecular
evolutionary dynamics and use of genomic data. Evolution of microsatellites.
Butterfly phylogenetics. Developed a new method for detecting evolutionary
interaction (coevolution) between protein residues. Coordinating a project
to obtain large regions of coding sequence from thousands of vertebrate
mitochondrial genomes, and developed methods to do this efficiently in
conjunction with genome centers. The goal of this is to demonstrate the
utility of sampling "genomic biodiversity" at this level in order to correlate
evolutionary dynamics with functional and structural features of proteins.
Importance sampling (i.e., sampling the posterior likelihood space) for
phylogenetic trees, and analyzing the effects of dense taxon sampling on
parameter estimation and topology reconstruction |
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