BIOLOGICAL COMPUTATION AND VISUALIZATION CENTER

Les Butler
BCVC
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E-Mail: lbutler@lsu.edu
Office:
Department of Chemistry
Louisiana State University
Baton Rouge, LA 70803-4001

Phone: (225) 388-4416

 
Research Interests Our major interest is the application of solid-state NMR techniques and synchrotron X-ray microtomography for solving problems in biological materials, heterogeneous catalysis, materials science, and hazardous waste solidification/stabilization. Thus, our work is highly interdisciplinary, and many research collaborations are involved.

Recently, we have developed new techniques for 27Al NMR. Aluminum is important in a new-generation catalysts for polypropylene. However, this co-catalyst, methylaluminoxane (MAO), while known for over 20 years, has a complex structure that is still unknown. Our techniques are showing promise for yielding structural information. Recently, we have:

* Developed field-swept NMR methods for use at the National High Magnetic Field Laboratory.
* Collaborated with Prof. Randall Hall's research group to interpret various NMR spectra.
* Developed a strong interaction with Albemarle, a leading manufacturer of MAO (NSF GOALIE grant).
* Expanded 27Al NMR work into biological applications such as the study of aluminum coordination with beta-amyloid plaques.
 
 

Now, we are also interested in microtomography. To us, it's just another way to look at solids. To others, it's a fascinating "fly through" of the solid. The three-dimensional data sets make great movies and inspire hypothesis-driven research. In the past, data was collected at the National Synchrotron Light Source at Brookhaven National Laboratory. We are now building our own tomography beamline at the LSU synchrotron. We hope to have first images in Fall, 2000.